Database : HANSEN Search on : SINERGISMO DE DROGAS [Subject descriptor] References found : 6 [refine] Displaying: 1 .. 6   in format [Detailed]

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Id: 13258 Author: Heifets, Leonid B Title: Synergistic effect of rifampin, streptomycin, ethionamide, and ethambutol on Mycobacterium intracellulare ..- Source: s.l; s.n; jan. 1982. 6 p. tab, graf. Abstract: A method of quantitative estimation to determine the interaction of antituberculosis drugs is suggested. The design of experiments, performed on 7H11 agar plates, is adjusted to the following statistical treatment by combined use of probit analysis and isobologram methods. By plotting the values reflecting the inhibition of 75% of the bacterial population (ED75) with their confidence limits on the isobologram, it was found that the clearest results proving synergism between the drugs could be obtained. Six 2-drug combinations and 6 3-drug combinations were tested against strains of Mycobacterium intracellulare (serovar 8), and a synergistic effect was demonstrated in most of them. These were various combinations of rifampin, streptomycin, ethambutol, and ethionamide. The application of probit analysis to the data derived from testing single drugs can provide a quantitative estimation of the actual drug resistance of the M. intracellulare strains.(AU). Descriptors: SINERGISMO DE DROGAS TESTES DE SENSIBILIDADE MICROBIANA MICOBACTERIAS ATIPICAS/ef drogas MYCOBACTERIUM/ef drogas ETAMBUTOL/farmacol ETIONAMIDA/farmacol RIFAMPINA/farmacol ESTREPTOMICINA/farmacol Limits: SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 00960/s

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Id: 12231 Author: Dhople, Arvind M Title: In vivo activity of epiroprim, a dihydrofolate reductase inhibitor, singly and in combination with dapsone, against mycobacterium leprae ..- Source: s.l; s.n; 2002. 4 p. tab. Descriptors: ADMINISTRAÇAO ORAL TATUS DAPSONA DAPSONA SINERGISMO DE DROGAS ANTAGONISTAS DO ACIDO FOLICO ANTAGONISTAS DO ACIDO FOLICO LEPROSTATICOS LEPROSTATICOS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS BALB C MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE TRIMETOPRIM TRIMETOPRIM TRIMETOPRIM Limits: ANIMAL Location: BR191.1; 08715/s

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Id: 11720 Author: Aleman, M; Barrera, S. de la; Fink, S; Finiasz, M; Arinna, M. H; Pizzariello, G; Sasiain, M. del C Title: Interleukin-12 amplifies the M. leprae hsp65-cytotoxic responses in the presence of tumor necrosis factor-alpha and interferon-gamma generating CD56+ effector cells: interleukin-4 downregulates this effect ..- Source: s.l; s.n; 2000. 9 p. tab, graf. Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE ANTIGENOS CD56 CHAPERONINAS CITOTOXICIDADE IMUNOLOGICA SINERGISMO DE DROGAS SOROS IMUNES INTERFERON TIPO II INTERLEUCINA-10 INTERLEUCINA-12 INTERLEUCINA-12 INTERLEUCINA-12 INTERLEUCINA-4 INTERFASE LEUCOCITOS MONONUCLEARES LEUCOCITOS MONONUCLEARES TRANSFORMAÇAO LINFOCITICA COMPLEXO PRINCIPAL DE HISTOCOMPATIBILIDADE LIGAÇAO PROTÉICA LINFOCITOS T CITOTOXICOS LINFOCITOS T CITOTOXICOS FATOR DE NECROSE DE TUMOR FATOR DE NECROSE DE TUMOR FATOR DE NECROSE DE TUMOR Location: BR191.1; 07463/s

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Id: 11285 Author: Dhople, A. M; Ibanez, M. A Title: In vivo susceptibility of mycobacterium leprae to ofloxacin either singly or in combination with rifampicin and rifabutin: anti-leprosy activity of ofloxacin and ansamycins in mice ..- Source: s.l; s.n; 1994. 3 p. tab. Descriptors: TATUS SINERGISMO DE DROGAS PÉ LEPROSTATICOS HANSENIASE HANSENIASE FIGADO CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS BALB C MYCOBACTERIUM LEPRAE OFLOXACINA RIFABUTINA RIFAMPINA Limits: ANIMAL Location: BR191.1; 07224/s

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Id: 10189 Author: De Jong, Rolien; Janson, Anneke A. M; Faber, William R; Naafs, Ben; Ottenhoff, Tom H. M Title: IL-2 and IL-12 act in synergy to overcome antigen-specific T cell unresponsiveness in mycobacterial disease ..- Source: s.l; s.n; 1997. 8 p. tab, graf. Descriptors: SINERGISMO DE DROGAS IMUNIDADE CELULAR INTERLEUCINA-12 INTERLEUCINA-12 INTERLEUCINA-2 INTERLEUCINA-2 TRANSFORMAÇAO LINFOCITICA PROTEINAS RECOMBINANTES LINFOCITOS T Location: BR191.1; 07102/s

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Id: 9327 Author: Kumar, Dinesh B; Prasad, Eshwar C; Krishnaswamy, Kamala Title: Detection of rifampicin-induced nephrotoxicity by N-acetyl-3-D-glucosaminidase activity ..- Source: s.l; s.n; 1992. 4 p. graf. Descriptors: HANSENIASE ANTIBIOTICOS COMBINADOS ANTIBIOTICOS COMBINADOS ESTUDOS TRANSVERSAIS SINERGISMO DE DROGAS TAXA DE FILTRAÇAO GLOMERULAR RIM RIFAMPINA RIFAMPINA ESTREPTOMICINA ESTREPTOMICINA TUBERCULOSE PULMONAR Limits: HUMANO MEIA-IDADE Location: BR191.1; 06474/s

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